Construção e análise de modelos topológicos de redes biológicas usando a ontologia MONET

Abstract

One of the most important challenges for biology in the post-genomic is to understand the structure and behavior of the molecular interactions that controls cell behavior.

Therefore is essential to integrate biological data concerning these interactions, which are stored in different databases. The integration task is dificult because these data are distributed in public databases on the world wide web and each database has diferent management systems, formats and views of how to represent biological data. The two main problems involved here are the dificulty in parsing the data when dealing with heterogeneous

at file formats and the inconsistencies due to the absence of an united vocabulary. As an alternative to facilitate these problems this work proposes MONET (the Molecular Network) ontology, an integration model for the unifying of diferent molecular networks that exist inside the cell. Such integrated view facilitates the understanding of

the large-scale interactions responsible for the behavior of